hypoactivate

hypo- +‎ activate

IPA^(key): /ˌhaɪ.poʊˈæktɪveɪt/

hypoactivate (third-person singular simple present hypoactivates, present participle hypoactivating, simple past and past participle hypoactivated)

1. (physiology, psychology) To reduce the level of activation or activity of (a process, region, or function), especially in biological or neural contexts.
   • 1974, George Bernard Whatmore, Daniel R. Kohli, The Physiopathology and Treatment of Functional Disorders: Including Anxiety States and Depression and the Role of Biofeedback Training, Grune & Stratton, page 76:

     Among the various effects, they hyperactivate, hypoactivate, or inhibite limbic and other circuits, disorganize circuit activity, and interfere with effective functioning of the organism.

   • 2015 March 30, Allan Tasman, Jeffrey A. Lieberman, Jerald Kay, Michael B. First, Michelle Riba, editors, Psychiatry, Fourth edition, volume 2, Wiley, page 251:

     If the DLPFC of schizophrenic patients operates less efficiently than that of controls, patients may be found to hyperactivate this region as they strain to keep up with low working memory loads that control subjects can easily handle, and hypoactivate this region at higher working memory loads that exceed patients’ working memory capacity, but not that of controls.

   • 2025 July 17, Wikipedia contributors, “Caenorhabditis elegans”, in English Wikipedia‎^[1], Wikimedia Foundation:

     The mix-1 gene is known to hypoactivate the X chromosome and regulates the morphology of the male tail in C. elegans.

• inhibit
• downregulate

• hypoactivation

• hyperactivate
• hypoactivity